Among the 465 genes, expression differences between alcohol-naïve rats from 5 selectively bred pairs of high-drinking and low-drinking rats were found for 138 of the genes that differed at baseline, eQTLs from lymphocytes (GTEx) affected 83 of these genes, and 6 were found in the NHGRI catalog (Supplemental Table 4). Three GWAS genes, CASZ1 (castor zinc finger 1), MREG (melanoregulin) and ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1), were affected by ethanol with a direction opposite those for AD vs. controls.
