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Chunk #72 — Online Methods — Identification and evaluation of candidate tumor purity and ploidy values

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Absolute quantification of somatic DNA alterations in human cancer.
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By definition, this quantity (τ̂g) is an alternate estimate of cancer ploidy (note an additional factor of 2 is added when HSCRs are used). Because (τ̂g) is a weighted average over discrete states in the modeled data, it is expected to be more robust to experimental fluctuations that shift or scale the copy-profile slightly. Note that, for this computation, the q̂ij were calculated with θ̂z = 0, so that the above expectation is over integer states only.