Chunk #59 — Methods — GWAS fine-mapping

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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Polygenic functionally informed fine-mapping (PolyFun)30 software was used to annotate our results data with per-SNP heritabilities, as derived from a meta-analysis of 15 UK Biobank traits. PTSD risk loci were fine-mapped using SUSIE106, with these per SNP heritabilities used as priors, pre-computed UKB-based summary LD information used as the LD reference, and locus start and end positions as determined by FUMA. The SUSIE model assumed a maximum of two causal variants.