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Chunk #14 — Results — Polymorphisms of DRD1, DLG4 and HOMER1 are associated with opiate abuse

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Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels.
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To account for multiple SNPs tested, Bonferroni corrections were performed on association results. The most significant DLG4 SNP (rs507506) remained statistically significant after correction (P=0.0016). Following correction in the Caucasian population, two DLG4 SNPs were significant (rs2521985, P=0.016; rs507506, P=0.03), while a trend for an association was observed for a DRD1 SNP (rs265975, P=0.09). No significant associations remained after correction in the African American population.