Finally, Zfhx1b mutants did not exhibit clear phenotypes of striatal cholinergic interneurons or the GP. Thus, we propose a distinct Zfhx1b-independent mechanism for the generation of the GP and cholinergic neurons; the latter depends on the maintenance of Lhx8, perhaps in combination with Islet1 and Gbx2 (Chen et al., 2010; Fragkouli et al., 2009).
