Using existing GWAS data, we investigated genetic associations between liabilities to four eating disorder and eight substance use-related phenotypes spanning initiation and typical use to dependence. We found specific patterns of association between the two diagnostic categories for eating disorders, suggesting that differences between AN and BN, and between AN subtypes, with substance use-related phenotypes may point toward substance-specific genetic relationships. Additionally, there may be some degree of symptom overlap contributing to these associations.
