for these loci using GCTA with EUR summary statistics and 1000G data as reference LD. This analysis confirmed that there are only four independent signals, i.e. no associated region reflected more than one independent signal. The other three associated regions map to chromosome 17, lead SNP rs77804065 (p=1.5×10−12; Supplementary Figure 4a), at CRHR1, corticotropin-releasing hormone receptor 1, with the protein product of this gene involved in stress and immune responses (numerous additional GWS SNPs were found in the chromosome 17 region, including variants that map to KANSL1, KAT8 Regulatory NSL Complex Subunit 1); chromosome 8, lead SNP rs7821592 (p=3.6×10−08; Supplementary Figure 4b), closest gene XPO7, exportin 7, the protein product of which mediates nuclear export of proteins; and chromosome 10, lead SNP rs1577857 (p=4.2×10−08; Supplementary Figure 4c), at LOC105378478, which has unknown function (closest gene, RNU6–53P).
