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Chunk #65 — METHODS — Polygenic score (PGS) analysis of cognitive measures in PNC.

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
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The total variance explained by ADHD-PGS and model covariates for each neurocognitive phenotype was reported using Adjusted R2. Additionally, the variance explained by ADHD-PGS was calculated in R using a variance partitioning tool (https://github.com/GabrielHoffman/misc_vp/blob/master/calcVarPart.R). Reported P-values were Bonferroni-adjusted to account for the number of independent tests performed.