Genomewide significant association for ANYDEP was observed with a SNP in an uncharacterized gene, LOC151121 (p=1.8×10−8). Further evidence of association was corroborated by surrounding SNPs, both genotyped and imputed. Nominal replication was found in the SAGE sample (p=0.02) with the same phenotype. This SNP was moderately associated with QUANTDEP (p=3.8 ×10−5) and also with the number of DSM-IV alcohol dependence criteria endorsed (symptom count) in another related study with data from the same sample (p=7.2×10−5), (Wang et al., 2013). Similar to the replication results here, this SNP was nominally associated with the alcohol dependence symptom count in the SAGE sample as well (p=0.014) (Wang et al., 2013).
