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Chunk #24 — Discussion

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Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.
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In the context of this study, it is useful to compare results for specific SNPs, phenotypes, and samples to those that have been previously reported. To facilitate this process, Supplementary Table 1 summarizes results from the four other publications to compare with new data presented here. The fourth column gives the allele of each SNP present in the most common haplotype using data from the caucasian HapMap sample. It is important to recognize that some of the studies included subjects from other ethnic backgrounds, including hispanics in the CADD sample and African Americans in the Add Health sample, where allele frequencies were found to differ. Therefore, although the risk alleles for individual SNPs across studies are in agreement for much of this region, there are some instances where they differ. It is possible that certain alleles of specific SNPs exert different effects among different ethnic groups, consistent with the fact that in animal models, the effect of a gene deletion may differ depending on genetic background (Crabbe et al, 2006). In this NYS sample of adults, results from the DSM-IV