with complete OPRM1 SNP genotypes and nicotine withdrawal sensitivity scores. Eight of eighteen SNPs evaluated for family based association with the nicotine withdrawal sensitivity score had global P-values of less than 0.05 (Table 2). All eight SNPs with P-values < 0.05 have Q-values < 0.06. Five of these eight SNPs are located in IVS1, with one each in IVS3, IVS4 and IVS5. The non-synonymous SNP rs1799971, which has been investigated in numerous studies of substance dependence, has a P-value = 0.07 and a Q-value = 0.08 in this analysis.
