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Chunk #40 — 4. Discussion — 4.2. Diffusion Tensor Imaging measures

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Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder.
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overall task-related cortical activation (for a review see Pandey et al., 2012a), longer reaction-time (Pandey et al., 2015, Pandey et al., 2012b, Smith et al., 2014), and longer event-related potential (ERP) peak latencies (Porjesz et al., 1987, Schuckit et al., 1988, Smith et al., 2014) while performing cognitive and motor tasks, which are indicators of resource allocation for response strength and associated cortical processing speeds in individuals with AUD. Given that impulsive and premature response tendencies are characteristic of AUD, these frequently reported findings may seem counterintuitive. However, Lawrence et al. (2009) have suggested that impaired inhibitory control in alcoholism occurs in the context of psychomotor slowing. Future research involving longitudinal structural and functional aspects in AUD can specifically test these hypotheses.