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Chunk #7 — Methods and Materials — Mediation/Moderation Modeling

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The AVPR1A gene and substance use disorders: association, replication, and functional evidence.
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We assessed mediation of association between an AVPR1A SNP (rs11174811) and DUD risk in adult male subjects (CEDAR sample) by a measure of spousal satisfaction from the Dyadic Relationship Scale of the Family Assessment Measure (FAM) (26). This relationship, with a latent FAM variable as a mediator, while modeling the latter's factor structure, was tested using Mplus (27).