The full meta-analysis was performed on 63,030 subjects from 29 discovery cohorts. All samples were of European origin. Twenty-one cohorts were from Europe, six from the United States and two from Australia. Sample sizes of the individual cohorts ranged from 177 to 7210 subjects. Please note that some cohorts were also part of previously published GWA studies on extraversion. The Generation Scotland: Scottish Family Health Study (GS:SFHS) cohort was included as a replication sample (9,783 subjects). A brief overview of all cohorts is provided in Table 1. A description of each individual cohort is found in the Supplementary materials and methods (see also De Moor et al. 2015).Table 1Overview of 29 discovery cohorts and 1 replication cohort of the Genetics of Personality ConsortiumCohort# Subjectsa # SNPsb 1ALSPAC47056,454,1532BLSA8204,989,4113BRESCIA1773,549,9194CHICAGO3113,755,4165CILENTO6271,123,0896COGA6475,127,1017COGEND12795,932,8388EGCUT11845,574,6959ERF23005,142,86510FTC EPI5674,870,09611FTC NEO8135,092,01812HBCS14565,612,79013CROATIA-Korcula8085,094,03414LBC19214374,363,61115LBC19369525,168,75416MCTFR70996,569,99917MGS21015,900,89818NBS18325,603,44719NESDA22274,707,56920NTR64165,339,79821ORCADES16504,265,59022PAGES4764,547,29323QIMR adolescents28425,957,06424QIMR adults72106,343,92025SardiNIA43326,291,13526SHIP22135,913,42827STR49036,519,09428CROATIA-Vis9095,327,67129YFS17375,914,679Total63,0307,460,14730GS:SFHS978374 NA Not Applicable for replication cohort because only top hits were sought to replicate aNumber of subjects with valid latent score for Extraversion and SNP data (after imputation and cleaning) bNumber of SNPs (after imputation and cleaning) with valid association results that entered the meta-analysis
