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Chunk #0 — Introduction

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Genetic association study of childhood aggression across raters, instruments, and age.
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There is a variety of phenotypic definitions of aggressive behavior (AGG), from broadly defined externalizing problems to narrow definitions like chronic physical aggression [1]. Generally any action performed with the intention to harm another organism can be viewed as AGG [2, 3]. AGG is considered a common human behavior [4], with people varying in the degree of AGG they exhibit [5]. Children typically display AGG early in life, after which symptoms tend to diminish [6, 7], although in some individuals AGG persists into adulthood [8]. AGG is also part of numerous childhood and adult disorders [9], including oppositional defiant disorder and conduct disorder (CD) [10]. In its extreme forms, AGG may be considered a disorder by itself—inflicting a huge personal and financial burden on the individual, their relatives, friends, and society as a whole [11]. In general population studies, AGG is commonly treated as a quantitative trait, and pathological AGG has been argued to be best seen as the extreme end of such a continuum [12–14]. Childhood AGG co-occurs with many other behavioral, emotional, and social problems [15, 16] and