association remained statistically significant (p=0.0015), the adjusted odds ratio for the standardized score dropped from 1.55 (95% CI 1.42–1.69) to 1.25 (95% CI 1.08–1.44) and the proportion of variance explained dropped from 3.7% to 0.7%. Therefore, we cannot rule out the possibility that the observed association between any substance use disorder and schizophrenia polygenic risk score is primarily driven by tobacco use disorder.
