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Chunk #10 — Materials and Methods — Procedures

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Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
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CASE sessions consisted of a free-access paradigm, Freibier (German for “free beer”), comprising a priming phase followed by ad libitum self-infusion (Zimmermann et al., 2008, 2009). Participants were instructed to self-administer alcohol at their discretion to achieve a level of intoxication that was pleasurable, while avoiding unpleasant effects. They were instructed not to interact with staff unless necessary, but could listen to music through headphones during the session. Participants remained seated for the 2-hour session with the exception of a scheduled bathroom break. Experimenter-obtained BrAC readings were entered into the software regularly for online adjustment of model-projected aBAC profiles (participants remained blind to BrAC readings). Subjective questionnaires occurred once before the infusion, immediately after the priming phase, and at intervals of ~30 minutes during the ad libitum phase. After the session participants relocated to a private room, where they were monitored and released after BrAC fell below 30mg%.