To validate this discovery, we applied MetaNeighbor to two independent scRNAseq datasets (Tasic et al., 2016; Zeisel et al., 2015). Despite differences in experimental design and methods our meta-analysis yielded high replicability on PCP-distinguishing gene families (Figure 2F). Nearly identical gene families best discriminated equivalent cell populations (i.e. 6 PCPs) in the three datasets, and the AUROC values of these families (Figure 2C) were well correlated in pair wise comparisons even though the scores from the other two datasets were modestly lower (Figure 2F).
