might suggest a particular role for right-sided functional abnormalities in schizophrenia-like disorders, and in particular in SLPE. Alternatively, this might be related to the fact that the majority of the patients with SLPE in this study had mesiotemporal epilepsy with predominant right seizure focus (63.2% of the patients had right temporal epilepsy). This observation gives rise to the speculation that resting-state functional hyperconnectivity between irritative areas subserving psychic symptoms (e.g., medial temporal cortex) and cortical regions involved in the DMN (e.g., ACC/mPFC) [19], [20] or in neuropsychological models of psychosis (e.g., DLPFC) [3], [6], [64]–[66] might be a mechanism underlying chronic psychosis in patients with epilepsy. This does not suggest a synchronized “epileptic” activity and warrants further investigation. The fact that pronounced abnormalities (e.g., slowing) were not observed in the temporal lobe supports the idea that an abnormal functional connection of this region with areas relevant to psychosis rather than a local cortical dysfunction may be a key factor in SLPE pathophysiology.
