Many smokers have successfully quit using a variety of smoking cessation pharmacotherapies. Yet there is little direct evidence on the relative efficacies of these different pharmacotherapies, and without such evidence clinicians and smokers lack a strong empirical basis for recommending or selecting from amongst them. The current paper reports data on the efficacies of five different smoking cessation pharmacotherapies. This research also evaluates the efficacy of the nicotine lozenge, providing additional information on a treatment that has been supported by only one placebo controlled study published to date. Finally, this research evaluates two different medication combinations, one of which (i.e., the nicotine patch + nicotine lozenge) has not been previously evaluated.