Although post-hoc analyses did indicate differences between the amphetamine prodrug lisdexamfetamine and other amphetamines, the few studies that we were able to include in this comparison (four studies of lisdexamfetamine in children and adolescents and one of amphetamines; and two studies of lisdexamfetamine in adults and one of amphetamines) prevent us from drawing any firm conclusions from these findings. We would, therefore, not feel confident at this stage to recommend lisdexamfetamine over the other amphetamines for adults, as was suggested by NICE, although based on UK costs.9
