Prediction accuracy was quantified in 61,095 unrelated individuals from three studies, including 33,001 participants of the UKB who were not included in our discovery GWAS (that is, 14,587 EUR; 9,257 SAS; 6,911 AFR and 2,246 EAS; Methods section ‘Samples used for prediction and estimation of variance explained’); 14,058 EUR participants from the Lifelines cohort study; and 8,238 HIS and 5,798 AFR participants from the PAGE study.