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Chunk #7 — Design of the COGA Study — Genetic Analysis

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Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism.
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The second method of genetic anal ysis examined quantitative phenotypes—traits that are present to varying degrees (e.g., the maximum number of drinks a person has consumed per occasion). The advantage of quantitative methods is that assessments are available on affected as well as unaffected people; thus, these methods have greater statis tical power because they include more people. Phenotypes studied using quantitative methods included the severity scale of alcohol dependence, level of response to alcohol, maximum number of drinks per occasion, and electrophysiological (i.e., EEG and ERP) measurements.