All definitions were based on recall of episodes or symptoms of depression by participants in the UK Biobank. As priming of recall by current mood affects the reliability of such reports19-21, we emphasize that each definition is noisy and can be interpreted as being enriched for individuals truly fulfilling its criteria. We explore further characteristics of all definitions and considerations in their GWAS in the Supplementary Note, Supplementary Figs. 2-5 and Supplementary Tables 2-11.
