to detect interactions. On a more conceptual level, we note that previous analyses using the FinnTwin12 data have established latent G×E effects for relationship status and intoxication frequency (Barr et al., in press). This gives us more confidence in the G×E results using measured genotypes. Finally, as with other tests of enrichment, the focus of this analysis was not on interpreting the direction of any of the SNP × Relationship Status effects themselves, but rather examining whether there was overall enrichment to inform future studies about “which SNPs and which genes” are worth carrying forward into studies of GxE using measured genotypes.
