There were no GWS associations in the smaller AA sample (Figure S2). The meta-analysis of the EA and AA results showed mostly similar results, with the exception of regions on chromosome 1 and chromosome 17, which improved in significance. In other regions, significance was similar to what was seen for EAs-only, but the position of the lead SNP sometimes shifted, and two regions were not GWS in the transpopulation meta-analysis (SPRK2, KCNIP4) (Table S5). The most noteworthy difference in the transpopulation meta-analysis was seen on chromosome 17 (Figure 2), where the association signal improved by over an order of magnitude and shifted from KANSL1 rs2532252 (p=4.5×10−10) to CRHR1 rs1724409 (p=3.55×10−11). Regional Manhattan plots for significant regions in EAs, AAs, and meta-analysis are presented in Figure S3.
