= 8.28 × 10−6) and “Coronary atherosclerosis” (OR, 1.10 [95% CI, 1.05–1.14]; P = 1.08 × 10−5). The phenome-wide association study of the polygenic score for loneliness (Fig. 2b) also found significant associations with “Mood disorders” (OR, 1.09 [95% CI, 1.05–1.14]; P = 1.39 × 10−5) and “Depression” (OR, 1.10 [95% CI, 1.05–1.14]; P = 1.43 × 10−5). The top associations, however, were with heart disease phenotypes, specifically, “Ischemic heart disease” (OR, 1.10 [95% CI, 1.06–1.14]; P = 2.91 × 10−6) and “Coronary atherosclerosis” (OR, 1.10 [95% CI, 1.06–1.15]; P = 5.89 × 10−6). In contrast, a polygenic score for CAD (Supplementary Methods) was not associated with MDD (OR, 0.93 [95% CI, 0.87–1.00]; P = 0.07), or other mental disorder diagnoses (P > 0.05; see above link to interactive plots and Supplementary Fig. 5), replicating previously published findings [35].
