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Chunk #3 — METHODS — Subjects

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Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.
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Prior to administration of the neurophysiology test battery, alcoholic subjects had been detoxified in a 30-day treatment program, and none of the subjects was in the withdrawal phase. Subjects were excluded from the neurophysiology protocol if they manifested any of the following: uncorrected sensory deficits, hepatic encephalopathy/cirrhosis of the liver, history of significant head injury, seizures or neurosurgical procedures, other acute/chronic medical illness, were on medication known to influence brain functioning (e.g., any psychotropic medications), or tested positive for HIV. Subjects were also excluded on the basis of recent (i.e., 5 days) substance and/or alcohol use, based on self-report as well as breath-analyzer and urine screen. In addition, all subjects were screened for cognitive status, using the Mini Mental State Examination (MMSE, Folstein et al., 1975).