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Chunk #10 — Results — Multiple Regression Analyses — Implicit drinking motives and COMT

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COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use.
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Models evaluating drinking variables as a function of implicit coping motives and COMT (Table 2) revealed that main effects of COMT and implicit coping motives were not significant predictors of drinking, with the exception of a non-significant trend of COMT predicting drinks per week (p = .057). Consistent with predictions, cope IAT scores showed stronger associations with drinking outcomes among COMT Met carriers compared to COMT Val/Val individuals, supporting our moderation hypothesis (see Figure 1). This pattern of results held for both drinks per week and heavy drinking episodes, and a non-significant trend in the same direction was found for peak life drinks (p = .053).