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Chunk #4 — INTRODUCTION

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Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
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signaling pathways, neuropeptides and vesicular release components, and transcription factors. Combinatorial and coordinated expression of select family members across these categories shapes a molecular scaffold along the cell membrane that appears to customize the pattern and property of synaptic communication for each cell population. We further provide evidence that transcription factor profiles register the developmental history of GABAergic neurons and contribute to concerted gene expression patterns that shape cell phenotypes. These findings suggest that neuronal identity is encoded in a transcriptional architecture that orchestrates functionally congruent expression across multiple gene families to customize the patterns and properties of their input-output communication.