in these circuits to particular clinical profiles and treatment approaches [e.g. 11, 33–34]. To our knowledge, no published work has incorporated patients’ subjective reports of their experiences of symptoms or considered specific treatment strategies directed at a range of clinical profiles and neurocircuit alterations. It is important to note that in the following sections we present a simplified account of the functions of the five neurocircuits for the purposes of synthesizing a vast literature and providing coherent and testable hypotheses of links between specific clinical profiles and neurobiological alterations in each neurocircuit. However, we emphasize in advance that the functions of these neurocircuits are considerably more complex and not limited to the neurocognitive alterations we describe here. Likewise, the neurocircuits are highly interactive and not as segregated as they may appear in the following sections. We highlight some of these complexities as we discuss each circuit and consider them in more depth in the Limitations section at the end of the article.
