Among AIAN men and women, large absolute increases occurred throughout the age range, with the largest absolute increase occurring for ages 45 to 49 years among men (2000-2013: 113.6 deaths per 100 000 residents; 2013-2016: 193.1 deaths per 100 000 residents) and for ages 50 to 54 among women (2000-2013: from 56.1 deaths per 100 000 residents; 2013-2016: 105.1 deaths per 100 000 residents) (Figure 2); APCs were generally similar by age (Figure 3). For example, increases from ages 23 to 60 years ranged from 2.4% per year to 6.7% per year among men and from 2.8% per year to 6.1% per year among women, with no clear pattern. Among white individuals, increases in absolute rates from 2000 to 2003 and from 2013 to 2016 also occurred through much of the age range but particularly in midlife (eg, men aged 55-59 years, 2000-2003: 25.5 deaths per 100 000 residents; 2013-2016: 43.3 deaths per 100 000 residents; women aged 50-54 years, 2000-2003: 7.4 deaths per 100 000 residents; 2013-2016: 16.5 deaths per 100 000 residents) (Figure 2); APCs for ages 25
