studies of PPARG to include the gene for its transcriptional coactivator, PPARGC1A. We tested 46 SNPs and 3 provided support for an association with AD (8.6 × 10−3<p< 0.04) but none with withdrawal (p>0.07) (Figure 3C). In all regions with evidence supporting association (p<0.05), imputed SNPs were analyzed. The imputed SNPs in PPARGC1A provided additional evidence supporting the association with AD (p<0.001; Figure 3C).
