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Chunk #21 — Materials and Methods — Statistical Analysis — Analysis of the GADD sample — Adolescent/young adult alcohol abuse and dependence

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Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.
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Adolescent/young adult AAD symptoms were drawn from wave 1 of data collection. All items were assessed using DSM IV criteria. As in the CADD, only phenotypic data for subjects who had previously used alcohol were included. Of the 572 adolescent subjects with no dependence symptoms, 10.5% of them endorsed an abuse criterion. For standardization, the coefficients from the standardization of the adolescent AAD symptoms from the CADD community sample were applied to the GADD sample. After standardization, only phenotypic data from subjects between the ages of 10 and 25 were included. The analysis was performed on 1,186 subjects.