Chunk #42 — Results — Spatiotemporal expression of the DEGs during brain development and the co-expressed networks

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Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion.

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Next, we set out to address how our findings from in vitro neuronal cultures could be related to brain development. In particular, we asked what genes and pathways that are expressed during normal brain development could be impacted if the same set of genes were dysregulated in the brains of individuals with 22q11.2DS.