No study has concurrently combined MR-based neurobiological measures with comprehensive neurocognitive assessment in order to study the correspondence between brain function and neurocognition. Studies relating MR-based brain volumetric and metabolite measures to neurocognition in substance dependent populations have observed different patterns/relationships for smokers and non-smokers [182,183] suggesting a differential use of compensatory functions in smokers and non-smokers to accomplish the same task.
