To confirm that the association between CRHR1 and P3 found in the current study was not attributed to the genetic association with alcohol-dependent subjects, which are known to have low P3 amplitude in previous studies, we performed an additional transmission disequilibrium test (TDT) on the nonaffected subjects only. The results (Table 3) demonstrated that the association between the variations of CRHR1 and P3 amplitude is independent of the state of alcohol dependence.
