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Chunk #11 — Results — Multivariate GWAS of externalizing liability

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Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
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121 (21%) were new loci, not previously associated with any of the seven externalizing behaviors/disorders that went into the Genomic SEM model, and 41 (7%) can be classified as entirely novel, as they have not been reported previously for any trait in the GWAS literature (i.e., neither of these 41 SNPs nor any SNPs in LD (r2 > 0.1) were reported for any traits at two-sided P < 1×10−5 in the NHGRI-EBI GWAS Catalog6, version e96 2019-05-03) (Supplementary Table 10).