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Epigenomic annotation of genetic variants using the Roadmap Epigenome Browser.
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6–8). Additionally, investigators can explore multiple complete reference epigenomes in different Browser panels in parallel using synchronized genomic coordinates or independent genomic coordinates. A variety of EpiGenome Browser functions, including gene set view, genome juxtaposition, chromatin interaction display, and statistical testing can be applied to better engage with this epigenomic resource (Supplementary Notes, Tutorial 1, Supplementary Fig. 9). We also provide the means for investigators to build their own Data Hub Clusters of different scales and clone the Browser on Amazon Cloud to visualize and analyze private data in the context of public data (Tutorial 2). These tools, along with the rapidly growing epigenomic datasets of human cells of different states, will play a critical role in translating genetic signals into molecular mechanisms, leading to prognostic, diagnostic and therapeutic advances.