Key descriptive features of our cohort are depicted in the Table. Alcohol use disorder registration was associated with a substantially elevated mortality rate, with the mortality HR (mHR) controlling for sex, educational status, and year of birth estimated at 5.83 (95% CI, 5.76–5.90). However, the mHR was not constant over time, with a linear model suggesting a rapid decline with increasing age (age by AUD HR, 0.64; 95% CI, 0.64–0.65). Therefore, we examined the effect of AUD on mortality in our entire population as a function of age. As seen in Figure 1, the AUD-associated mHR began at 5.04 (95% CI, 4.38–5.79) in the youngest age group(15–24 years), increased with age reaching a maximum at ages 30 to 39 years (8.19; 95% CI, 7.90–8.50), and then began a slow monotonic decline until ages 65 to 70 years (4.14; 95% CI, 3.96–4.33).
