In the functional domain, we used CCA to explore whether patterns of functional coupling among DMN subregions were linked to functional connectivity changes between other macroscopical networks. Building on evidence of the DMN nodes as convergence zones of neural activity from the broader cortical system (7, 38), we used CCA to quantify how functional coupling shifts inside our group-defined DMN relate to functional coupling shifts between major brain networks distributed across the entire cortex. Our pattern search analysis highlighted major DMN nodes as possible hubs of interplay between distributed functional networks (16), providing evidence for a role of this system in two levels of brain organization usually studied in isolation: functional integration of common cortical networks and functional segregation of local specialized regions.
