exact test statistics corresponding to the synonymous collapsing model. At the tail of this distribution, we identified two genuine relationships: MACROD1 synonymous variants correlating with decreased levels of ‘Urate’ (P = 2.8 × 10−30)56 and ALPL synonymous variants correlating with decreased levels of ‘alkaline phosphatase’ (P = 9.3 × 10−9)57. Following this, we saw a tail of P values beginning from P = 5.2 × 10−8 (Supplementary Table 20).
