On the other hand, enhancement of PAC at rest could reflect the abnormal, or abnormally frequent, generation of brief cortical states resembling preparatory population activity without an intention to move. In this way, both the enhanced resting PAC and the reduced dynPAC modulation could be caused by the dysfunction of a single (subcortical) mechanism that controls or regulates the generation of cross-frequency couplings in cortical microcircuits. However, in the absence of direct evidence, the nature of the link between abnormally enhanced PAC at rest and abnormal modulation of dynPAC must remain a topic for future investigations.
