increased density of VGLUT1, suggesting a dose-dependent relationship between the MECP2 gene and glutamate transport. Interestingly, overexpression of MECP2 is also pathogenic, and recently, a primate model of MECP2 overexpression showing autism-like social deficit has been generated72. A human hiPSC model for MECP duplication syndrome (MECP2dup), established by Nageshappa et al. showed that cortical neurons derived from affected hiPSC lines have increased synaptogenesis and dendritic complexity as well as altered neuronal network synchronization 73.
