Chunk #14 — Alcohol, Neuroimmune Signaling, and Neurodegeneration

Source

Neuroimmune Function and the Consequences of Alcohol Exposure.

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In summary, ethanol can directly increase NF-κB–mediated transcription of proinflammatory genes in the brain as well as decrease trophic protective-factor transcription by reducing CREB transcription. Together, these effects decrease the brain’s resilience to insults.