striatum fail to affect dopamine levels or alter dopamine clearance in DAT KO mice (Budygin, John, Mateo, & Jones, 2002; Mateo, Budygin, John, Banks, & Jones, 2004; Mateo, Budygin, John, & Jones, 2004; Shen, et al., 2004). By contrast, local injection experiments have shown the locus of the fluoxetine and cocaine effects in DAT KO mice to be in the ventral tegmental area (Mateo, Budygin, John, & Jones, 2004), consistent with an excitatory serotonergic input that must be somewhat different in DAT KO mice from the usual circumstance in wildtype mice.
