In this light, Bansal et al.86 recently considered the analysis of sequencing data obtained on two genes, FAAH and MGLL, thought be associated with morbid obesity among 142 morbidly obese and 147 control subjects discussed in a previous study66. They applied 11 of the methods described in this review plus 9 high-dimensional regression procedures, and showed that the methods do not consistently agree on the most strongly associated regions of the genes or the most likely causal variants. Their results emphasize the need for simulation and theoretical studies of different methodologies.
