studies focused on the effects of selection and the apparent inverse genetic relationship between preference and acute ethanol withdrawal. The current high and low preference lines were tested for differences in acute withdrawal following a 4 g/kg alcohol challenge; none were detected (data not shown). These studies also showed that there was no difference between the selected lines in the loss of and recovery of the righting reflex. The selected lines were not tested for differences in preference for other tastants. However, among the HS-CC founders, there is only a weak correlation (r = 0.21; N = 96) between preference for ethanol and preference for 0.2% saccharin.
