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Chunk #10 — Results — Expression of Bdnf in the mPFC is down-regulated in postpartum female mice

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The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice.
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same time, significant correlations were also observed between sucrose preference (p = 0.004), latency (p = 0.027), and immobility (p = 0.016) and BDNF protein levels in the mPFC (Fig. 2e). However, there were no significant correlations between sucrose preference (p = 0.675), latency (p = 0.606), and immobility (p = 0.527) and Bdnf mRNA levels in the hippocampus (Fig. 2f). The Bdnf gene contains multiple exon-specific transcripts. Therefore, we measured the Bdnf-specific exon mRNA levels in the mPFC of CUS-treated postpartum mice. The results show that exon I, exon II and exon VI levels were significantly decreased, while exon III and exon IV levels were unchanged (Additional file 1: Supplementary Fig. 1, Exon I: p = 0.028; Exon II: p = 0.028; Exon III: p = 0.165; Exon IV: p = 0.227; Exon VI: p = 0.003).