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Chunk #25 — Results — An Aminoacyl-tRNA Synthetase trans-QTL in Distal Qrr1

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Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression.
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In the LXS hippocampus dataset, Qrr1 has only a limited trans-effect on gene expression. Despite the weak effect, expression of Dars2 (probe ID ILM580427) maps to the distal part of Qrr1 at a LOD of 3. Although this is only a weak detection of the ARS QTL in the LXS dataset, it nonetheless demonstrates the strong regulatory effect of Qrr1 on the expression of this gene family. In the case of the CXB hippocampus dataset, not a single trans-QTL for the ARS is detected in Qrr1.